P-223: The Expression of Gp130 in Fallopian Tubes with Ectopic Tubal Gestation

Background: The transmembrane protein gp130 plays a central role in cytokine action as a signal transducing receptor subunit common to all interleukin-6 type cytokines. The expression of IL-6 is significantly increased near the implantation site in tubes with ectopic gestation as compared with normal.Thus, current study was designed to investigated the expression of gp130 in fallopian tubes with ectopic gestation Materials and Methods: Quantitative reverse transcriptase polymerase chain reaction to determine mRNA expressions of gp130 was performed in ampullaris parts of the fallopian tube of 12 women with ectopic tubal gestation at operation for tubal surgery. 12 non-pregnant women at luteal phase underwent hysterectomy and bilateral salpingo-oophorectomy for benign disease which did not affect the fallopian tubes , histological dating was carried out according to the criteria of Noyes et al. to confirm the luteal phase of the menstrual cycle women . Results: Expression of gp130 mRNAs was significantly lower in fallopian tube from women with ectopic tubal gestation compared to the nonpregnant woman (p<0.05). Conclusion: It is suggested that the decrease in gp130 expression in fallopian tube may be a risk factor for increased ectopic tubal gestation. gp130 expression was obviously high in midluteal phase fallopian tube which suggests that high levels of gp130 may contribute to embryo transportation into the uterus.